Which of the following is NOT a regional appellation of Burgundy?

The correct choice of Réserve Spéciale as not being a regional appellation of Burgundy is based on its classification. In Bourgogne, wine appellations are defined by specific regulations and geographical boundaries. Regional appellations, such as Bourgogne Rouge, Bourgogne Hautes Côtes de Beaune, and Bourgogne Côte Chalonnaise, reflect one of the broader levels of wine classification in the Burgundy region, indicating the wine's origin and quality standards.

Réserve Spéciale is not recognized as an official regional appellation within the Burgundy classification system. Instead, it typically refers to a style or designation used by producers to indicate a specific wine that may have been selected or blended from various parcels. While it might be used in marketing, it does not provide the specificity of origin associated with regional appellations and therefore does not fall within Burgundy's structured appellation system. This highlights the distinction between official regional classifications and names or terms that may be utilized for specific wines without regulatory backing.